Nitrogen generators for LC-MS applications

Stable nitrogen supply for precise LC-MS analysis

Modern LC-MS and LC-MS/MS systems place high demands on gas quality and supply reliability. A constant supply of nitrogen is crucial for stable ionisation, reproducible signal intensities and reliable fragmentation conditions – particularly in regulated laboratory environments such as pharmaceutical analysis, environmental analysis or clinical research.

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Nitrogen in LC-MS: Curtain gas and drying gas

Curtain gas

As a curtain gas, nitrogen stabilises the spray in the ionisation source, aids desolvation and protects the capillary system from matrix and solvent carry-over. Consistent gas quality ensures stable ionisation conditions, reduced chemical background and robust LC-MS methods.

Drying Gas

Nitrogen is also used as a drying gas, where it plays a key role in the evaporation of solvents at the interface. A constant, reliable gas supply ensures efficient desolvation, stable signal intensities and high sensitivity.

Chromalytic gas generators for LC-MS

Our gas generators supply high-purity nitrogen at constant pressure and with a stable flow rate – ideal for routine analyses and high-throughput laboratories. They completely replace gas cylinders, eliminate reliance on the supply chain and enhance safety in laboratory operations.Our nitrogen generators are compatible with LC-MS systems from Agilent, Waters, SCIEX, Shimadzu and Thermo Fisher Scientific – ranging from single-quadrupole to triple-quadrupole and QTOF platforms. The design is tailored to individual requirements based on gas demand, instrument type and application.
Advantages in laboratory operations:

reliable LC-MS and LC-MS/MS results
High analytical sensitivity down to the attogram range
Continuous gas supply without the need to change cylinders
Constant gas parameters for reliable measurement operation
Increased safety due to the elimination of high-pressure cylinders
Predictable, cost-effective laboratory workflows

Would you like to know which nitrogen generator is best suited to your LC-MS system? We’d be happy to help you choose.

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The SICOLAB mini ENDO has been specially developed for the ‘drying of endoscopes’ process. Ideally suited to this application, this solution can be used to dry gastroscopes, cystoscopes, bronchoscopes, uroscopes and ENT endoscopes from manufacturers such as Richard Wolf, Olympus, Karl Storz and Fujifilm.

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Questions and Answers

Analytical instruments require oil-free, dry and particle-free compressed air. These requirements usually correspond to the compressed air classes set out in ISO 8573-1, typically Class 1:3:1, in order to prevent measurement errors and contamination.

Rheometers often use compressed air for air bearings. Oil or moisture can impair the bearing’s function and adversely affect measurement accuracy.

Yes, if designed appropriately, a central compressed air station can supply several analysers. Alternatively, decentralised solutions such as the SICOLAB mini are a sensible option for individual units.

The SICOLAB is designed for higher flow rates and centralised applications, whilst the SICOLAB mini offers a compact solution for individual workstations and smaller analytical instruments.

Oil-free laboratory compressors significantly reduce maintenance requirements, as no oil changes are required and the risk of contamination is minimised.

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Phone: +49 7142 9022-0

Email: office@duerr-technik.de

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